Intradural cranial chordoma

Ito, Eiji; Saito, Kiyoshi; Nagatani, Tetsuya; Ishiyama, Junzo; Terada, Koichi; Yoshida, Mitsuhiro; Wakabayashi, Toshihiko

doi:10.1016/j.surneu.2009.01.003

« Previous Next »World Neurosurgery
Volume 73, Issue 3 , Pages 194-197, March 2010

Intradural cranial chordoma

Eiji Ito, MD
- Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan
Kiyoshi Saito, MD
- Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan
- Corresponding author. Tel.: +81 52 744 2353; fax: +81 52 744 2360.
Tetsuya Nagatani, MD
- Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan
Junzo Ishiyama, MD
- Department of Neurosurgery, Shizuoka Saiseikai General Hospital, Shizuoka 422-8527, Japan
Koichi Terada, MD
- Department of Neurosurgery, Hekinan Municipal Hospital, Hekinan 447-8502, Japan
Mitsuhiro Yoshida, MD
- Department of Neurosurgery, Yokkaichi Municipal Hospital, Yokkaichi 510-8567, Japan
Toshihiko Wakabayashi, MD
- Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan

Received 3 September 2008; accepted 5 January 2009. published online 31 March 2009.

Abstract

Background

Intradural chordomas are rare and have been considered benign owing to the feasibility of complete resection and the display of lesser aggressive biologic behavior than typical chordomas.

Case Description

We herein reported 2 cases of intradural cranial chordoma with aggressive biologic behavior. A tumor (anti–Ki-67 monoclonal antibody [MIB-1], 13.9%) in a 59-year-old woman was strongly adherent to the brainstem and involved the basilar artery and its branches. After subtotal removal, the remnant tumor was treated with stereotactic radiotherapy. A tumor (MIB-1, 6.2%) in a 75-year-old woman repeatedly recurred even after initial gross total removal. The recurrent chordomas were treated with γ-knife radiosurgery.

Conclusion

The cases presented in this study indicate that intradural chordomas can also be aggressive such as typical chordomas. Long-term follow-ups with a large number of patients with this condition are essential for elucidating the prognosis of intradural chordomas.

Abbreviation: CT, computed tomography, MRI, magnetic resonance imaging, MIB-1, anti–Ki-67 monoclonal antibody

Keywords: Intradural chordoma, Skull base surgery, Recurrence, MIB-1 labeling index