Elsevier

World Neurosurgery

Volume 83, Issue 5, May 2015, Pages 715-717
World Neurosurgery

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Clearing Your Mind: A Glymphatic System?

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In 2013 Iliff and Nedergaard (4) summarized their present thoughts in an article in Stroke, noting that astrogliosis is a final common pathway of many mechanistically distinct forms of neurological injury such as trauma, hemorrhage, and ischemia. In their work, the AQP4 expression in injured brain is chaotic, in contrast to the normal state of AQP4 activity preponderance in the perivascular spaces, which may impede clearance of interstitial waste, not limited to beta amyloid or other aggregates

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Cited by (7)

  • Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases

    2018, Progress in Neurobiology
    Citation Excerpt :

    The flow of CSF-ISF fluid through the brain parenchyma relies on astrocytic AQP4 water channels. In addition, cardiac, respiratory, and vasomotor pulsation patterns may contribute to the driving force of convective CSF fluid dynamics (Hui, 2015; Jiang et al., 2016). VRS, originally thought as a perivascular drainage pathway (Esiri and Gay, 1990; Zhang et al., 1990), are now considered to be the starting point of the glymphatic system.

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