Case ReportEn Bloc Resection and Reconstruction Using a Frozen Tumor-Bearing Bone for Metastases of the Spine and Cranium from Retroperitoneal Paraganglioma
Section snippets
History and Evaluation
A 61-year-old woman underwent retroperitoneal paraganglioma resection 12 years previously. Nine years after the primary surgery, she began to experience back pain. Initial clinical examination at another clinic revealed a spinal tumor at T6, and she was referred to our hospital for further evaluation and treatment. On admission, she reported significant back pain, which deteriorated her performance in activities of daily living (ADLs). However, she did not have any neurologic deficits. Computed
Discussion
Ayala-Ramirez et al. published findings of a retrospective study of 128 patients with malignant pheochromocytoma and paraganglioma.5 The majority of patients with malignant paragangliomas developed bone metastases (71%), with the most frequent sites of bone metastases being the spine (81%), sacrum and pelvis (67%), proximal and distal long bone (49%), and cranium (21%). Additionally, 38% of patients with metastases had bone metastases at the diagnosis of the primary tumor. With regard to SREs,
Conclusion
We encountered a case of malignant paraganglioma with bone metastases to the spine and the cranium. Our preferred treatment method of en bloc resection for the spinal and cranial metastases and reconstruction using liquid nitrogen frozen, tumor-bearing bone was successful. Three years postoperatively, the patient's ADL and QOL were preserved, there was no local recurrence, and the reconstructions were maintained.
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Conflict of interest statement: None of the authors received any relevant financial or material supports associated with this study.