Literature ReviewRegression of Pineal Lesions: Spontaneous or Iatrogenic? A Case Report and Systematic Literature Review
Introduction
The pineal gland is an endocrine gland located behind the third ventricle being involved in the regulation of physiologic processes such as the sleep–wake cycle. Tumors arising from the pineal region account for approximately 4% of pediatric intracranial neoplasms and less than 1% of intracranial neoplasms in general.1, 2 Tumors of the pineal region comprise germ cell tumors, tumors that arise from the pineal parenchyma and from adjacent tissue (meningioma, glioma, and metastases).3 Imaging findings and oncologic markers in serum and the cerebrospinal fluid (CSF) may help distinguish the different entities. We present a case of spontaneous regression of a pineal mass lesion, including a systematic review of the literature on spontaneously vanishing pineal lesions, and discuss possible causative mechanisms.
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Case Description
A previously healthy 5-year-old boy was admitted to an external children's hospital with an acute onset of headache, vomiting, and clouding of consciousness. Bacterial meningitis was diagnosed after CSF diagnostic with increased white cell count and low level of glucose and treated with cefuroxime for 7 days. Pathogenic germs were not found. A magnetic resonance imaging (MRI) scan was performed because of a known prothrombotic disorder to exclude cerebral venous sinus thrombosis. The MRI scan
Methods
This study was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement as reported previously.4, 5, 6, 7
Results
Our search identified 533 potential citations. After duplications were excluded, 417 studies were retrieved for abstract evaluation. Screening of abstracts and titles identified 20 articles for full-text evaluation. Based on the full-text screening, 11 studies met the inclusion criteria. The reasons for exclusion can be extracted from Figure 4. The most frequent reasons for excluding studies were animal studies and studies dealing with tumors other than pineal lesions. All studies included were
Discussion
Spontaneous regression of tumors is a rare phenomenon, with a regression rate in malignant tumors of 1/60,000–100,000 patients.18 Spontaneous regression of intracranial tumors has been reported for optic-pathway and hypothalamic gliomas associated with neurofibromatosis type I, metastasis of renal cell carcinoma, and malignant lymphoma.19, 20, 21 The exact triggering factors leading to regression are unknown. We report and discuss possible mechanisms of spontaneous regression in pineal tumors
Conclusions
We found 6 possible hypotheses explaining spontaneous pineal tumor regression. However, none of these mechanisms is evidentiary. We could see a clear tendency that for germinomas mechanisms such as diagnostic irradiation, application of steroids and immunologic mechanisms are favored, whereas gliomas and cysts tend to respond to surgical trauma and treatment of hydrocephalus.
In all reported cases and in our case, some kind of treatment was performed before manifestation of tumor regression.
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2021, Nagoya Journal of Medical Science
Conflict of interest statement: The authors declare that the article content was composed in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Stephanie Schipmann and Dennis Keurhorst contributed equally to the study.
Supplementary digital content available online.